People
Principal Investigator
Adam S. Sperling, MD, PhD
Assistant Professor of Medicine (Hematology)
Adam received his medical degree and PhD in Biological Chemistry from the University of California, Los Angeles in 2011, where he worked on mechanisms of epigenetic gene regulation in the lab of Dr. Michael Grunstein. He completed his residency in internal medicine at the Brigham and Women’s Hospital and his fellowship in Hematology and Oncology at the Dana-Farber Cancer Institute. He is board certified in Internal Medicine, Medical Oncology, and Hematology. He completed his post-doctoral fellowship in the laboratory of Dr. Benjamin Ebert and is now an Assistant Professor of Medicine at Harvard Medical School and the Brigham and Women’s Hospital. His research focuses on understanding the mechanisms of disease evolution from pre-malignant conditions and the development of drug resistance in multiple myeloma and other hematologic malignancies. In the clinic he cares for patients with multiple myeloma, monoclonal gammopathies and clonal hematopoiesis.
Current Lab Members
Emily Gallen
Postdoctoral Researcher
Emily is currently in her thesis pending year of the British Heart Foundation PhD Programme in Cardiovascular Science at University of Glasgow. She joined the Sperling Lab in May 2024 as a pre-doctoral fellow. Here, she will investigate the role of RUNX1 in therapy-related myelodysplastic syndrome and acute myeloid leukemia.
Rajiv Sharma, PhD
Senior Research Scientist
Rajiv received his B.A. in Cell and Molecular Biology with an emphasis in Immunology from the University of California, Berkeley, then earned a Ph.D. in Gene Therapy & Vaccines at the University of Pennsylvania under the mentorship of Dr. Kathy High at the Children’s Hospital of Philadelphia. For his dissertation research, he focused on in vivo genome editing for Hemophilia and other monogenic disorders. He completed a postdoctoral fellowship with Dr. Ravindra Majeti at Stanford University, where he used CRISPR/Cas9 genome editing to investigate the clonal evolution of acute myeloid leukemia (AML). He is interested in novel applications of molecular techniques to advance the understanding and treatment of disease.
Lab Alumni
Vanessa A Quevedo Barrios, BA
Vanessa graduated from Williams College in 2021 where she majored in Chemistry and Arabic. She spent two years in the Sperling Lab as a research associate and is now pursuing a PhD at the University of Michigan.
Jonah F Boardman, BS
Jonah graduated from Brown University with a BS in Biochemistry. He joined the Sperling lab in July of 2023. His research focuses on the regulation of cell surface markers in hematological malignancies.
Sisasenkosi Mandi, BSc
Sisa received her Bachelor of Science degree from Brown University, where she majored in Biology. She joined the Sperling Lab in July of 2022. Here, her research focuses on understanding hematological malignancies and mechanisms of resistance.
Emma Grace Pittard, BS
Emma Grace received a B.S. in Biomedical Engineering at the University of South Carolina. She joined the Sperling lab in July 2024. Her research focuses on discovering key biological features of hematological malignancies.
Ravi K. Dutta, PhD
Ravi received his PhD from the Department of Biomedical and Clinical Sciences, Linköping University, Sweden. He joined the Sperling Lab in November of 2021. His research focuses on understanding the mechanism of thalidomide analog resistance in multiple myeloma.
Anuja Paudyal, PhD
Anuja received her PhD from the Division of Biology at Kansas State University. She joined the Sperling Lab in January of 2023. Her research focuses on understanding the DNA damage response after drug treatment and during the development of clonal hematopoiesis and hematologic malignancies.